Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells.

ABSTRACT: Planar cell polarization represents the ability of cells to orient within the plane of a tissue orthogonal to the apical basal axis. The proper polarized function of multiciliated cells requires the coordination of cilia spacing and cilia polarity as well as the timing of cilia beating during metachronal synchrony. The planar cell polarity pathway and hydrodynamic forces have been shown to instruct cilia polarity. In this paper, we show how intracellular effectors interpret polarity to organize cellular morphology in accordance with asymmetric cellular function. We observe that both cellular actin and microtubule networks undergo drastic reorganization, providing differential roles during the polarized organization of cilia. Using computational angular correlation analysis of cilia orienta

SUBMITTER: Werner ME 

PROVIDER: S-EPMC3187709 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature