A theoretical framework for estimating cerebral oxygen metabolism changes using the calibrated-BOLD method: modeling the effects of blood volume distribution, hematocrit, oxygen extraction fraction, and tissue signal properties on the BOLD signal.

ABSTRACT: Calibrated blood oxygenation level dependent (BOLD) imaging, a technique used to measure changes in cerebral O(2) metabolism, depends on an accurate model of how the BOLD signal is affected by the mismatch between changes in cerebral blood flow (CBF) and cerebral metabolic rate of O(2) (CMRO(2)). However, other factors such as the cerebral blood volume (CBV) distribution at rest and with activation also affect the BOLD signal. The Davis model originally proposed for calibrated BOLD studies (Davis et al., 1998) is widely used because of its simplicity, but it assumes CBV changes are uniformly distributed across vascular compartments, neglects intravascular signal changes, and ignores blood-tissue signal exchange effects as CBV increases and supplants tissue volume. More recent studies sugge

SUBMITTER: Griffeth VE 

PROVIDER: S-EPMC3187858 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature