Ontology highlight
ABSTRACT:
SUBMITTER: Delmore JE
PROVIDER: S-EPMC3187920 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Cell 20110901 6
MYC contributes to the pathogenesis of a majority of human cancers, yet strategies to modulate the function of the c-Myc oncoprotein do not exist. Toward this objective, we have targeted MYC transcription by interfering with chromatin-dependent signal transduction to RNA polymerase, specifically by inhibiting the acetyl-lysine recognition domains (bromodomains) of putative coactivator proteins implicated in transcriptional initiation and elongation. Using a selective small-molecule bromodomain i ...[more]