Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: implications for MRI contrast agents.

ABSTRACT: Eight-coordinate hydroxypyridinone/terephthalamide GdIII complexes display high relaxivities due to their two inner sphere water molecules. This relaxivity can be further increased by functionalizing the terephthalamide moiety with an amine. A significant hydrogen bonding interaction between the amine and another water molecule close to the GdIII apparently facilitates its coordination on the open site of the metal. The resulting nine-coordinate complex has three inner sphere water molecules, while maintaining high stability and fast ligand exchange rates.

SUBMITTER: Pierre VC 

PROVIDER: S-EPMC3188315 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature