Total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate.

ABSTRACT: We report the first total synthesis of (-)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural product.

SUBMITTER: Huters AD 

PROVIDER: S-EPMC3188348 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature