Chemoprevention of colon cancer in a rat carcinogenesis model using a novel nanotechnology-based combined treatment system.

ABSTRACT: Colorectal cancer (CRC) is the third most common cause of cancer death in the United States, accounting for approximately 51,000 deaths each year. We have previously shown in vitro chemopreventive effects of mixtures of aspirin, folic acid, and calcium (AFAC) on colon cancer cell lines. The objective of the present study was to evaluate the in vivo effects of orally administered, colon targeted chemopreventive combination regimens on the inhibition of aberrant crypt foci (ACF) in a rat model of colon carcinogenesis using (i) unmodified (free drug) combinations of AFAC and (ii) nanoparticle-encapsulated combinations of the same agents. A 14-week animal study was conducted in three phases to determine an optimal effective dose from AFAC combinations and evaluate the efficacy of nanotechnolog

SUBMITTER: Chaudhary A 

PROVIDER: S-EPMC3188363 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature