Functional viability profiles of breast cancer.

ABSTRACT:

Unlabelled

The design of targeted therapeutic strategies for cancer has largely been driven by the identification of tumor-specific genetic changes. However, the large number of genetic alterations present in tumor cells means that it is difficult to discriminate between genes that are critical for maintaining the disease state and those that are merely coincidental. Even when critical genes can be identified, directly targeting these is often challenging, meaning that alternative strategies such as exploiting synthetic lethality may be beneficial. To address these issues, we have carried out a functional genetic screen in >30 commonly used models of breast cancer to identify genes critical to the growth of specific breast cancer subtypes. In particular, we describe potential new t

SUBMITTER: Brough R 

PROVIDER: S-EPMC3188379 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature