Hydrophobicity and charge shape cellular metabolite concentrations.

ABSTRACT: What governs the concentrations of metabolites within living cells? Beyond specific metabolic and enzymatic considerations, are there global trends that affect their values? We hypothesize that the physico-chemical properties of metabolites considerably affect their in-vivo concentrations. The recently achieved experimental capability to measure the concentrations of many metabolites simultaneously has made the testing of this hypothesis possible. Here, we analyze such recently available data sets of metabolite concentrations within E. coli, S. cerevisiae, B. subtilis and human. Overall, these data sets encompass more than twenty conditions, each containing dozens (28-108) of simultaneously measured metabolites. We test for correlations with various physico-chemical properties and find tha

SUBMITTER: Bar-Even A 

PROVIDER: S-EPMC3188480 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature