Coexistence of lateral and co-tuned inhibitory configurations in cortical networks.

ABSTRACT: The responses of neurons in sensory cortex depend on the summation of excitatory and inhibitory synaptic inputs. How the excitatory and inhibitory inputs scale with stimulus depends on the network architecture, which ranges from the lateral inhibitory configuration where excitatory inputs are more narrowly tuned than inhibitory inputs, to the co-tuned configuration where both are tuned equally. The underlying circuitry that gives rise to lateral inhibition and co-tuning is yet unclear. Using large-scale network simulations with experimentally determined connectivity patterns and simulations with rate models, we show that the spatial extent of the input determined the configuration: there was a smooth transition from lateral inhibition with narrow input to co-tuning with broad input. The tr

SUBMITTER: Levy RB 

PROVIDER: S-EPMC3188483 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature