A multi-cell, multi-scale model of vertebrate segmentation and somite formation.

ABSTRACT: Somitogenesis, the formation of the body's primary segmental structure common to all vertebrate development, requires coordination between biological mechanisms at several scales. Explaining how these mechanisms interact across scales and how events are coordinated in space and time is necessary for a complete understanding of somitogenesis and its evolutionary flexibility. So far, mechanisms of somitogenesis have been studied independently. To test the consistency, integrability and combined explanatory power of current prevailing hypotheses, we built an integrated clock-and-wavefront model including submodels of the intracellular segmentation clock, intercellular segmentation-clock coupling via Delta/Notch signaling, an FGF8 determination front, delayed differentiation, clock-wavefront r

SUBMITTER: Hester SD 

PROVIDER: S-EPMC3188485 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature