Ictal high-frequency oscillations in neocortical epilepsy: implications for seizure localization and surgical resection.

ABSTRACT:

Purpose

To investigate the characteristics of intracranial ictal high-frequency oscillations (HFOs).

Methods

Among neocortical epilepsy patients who underwent intracranial monitoring and surgery, we studied patients with well-defined, unifocal seizure onsets characterized by discrete HFOs (≥70 Hz). Patients with multifocal or bilateral independent seizure onsets, electroencephalography (EEG) acquired at <1,000 Hz sampling rate, and nonresective surgery were excluded. Based on a prospectively defined protocol, we defined the seizure-onset zone (SOZ) presurgically to include only those channels with HFOs that showed subsequent sustained evolution (HFOs+ channels) but not the channels that lacked evolution (HFOs- channels). We then resected the SOZ as defined above, 1 cm of the

SUBMITTER: Modur PN 

PROVIDER: S-EPMC3188690 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature