Bringing order to protein disorder through comparative genomics and genetic interactions.

ABSTRACT:

Background

Intrinsically disordered regions are widespread, especially in proteomes of higher eukaryotes. Recently, protein disorder has been associated with a wide variety of cellular processes and has been implicated in several human diseases. Despite its apparent functional importance, the sheer range of different roles played by protein disorder often makes its exact contribution difficult to interpret.

Results

We attempt to better understand the different roles of disorder using a novel analysis that leverages both comparative genomics and genetic interactions. Strikingly, we find that disorder can be partitioned into three biologically distinct phenomena: regions where disorder is conserved but with quickly evolving amino acid sequences (flexible disorder); regions of

SUBMITTER: Bellay J 

PROVIDER: S-EPMC3188796 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature