Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line.

ABSTRACT: Tissue morphogenesis and cell sorting are major forces during organ development. Here, we characterize the process of tissue morphogenesis within the zebrafish lateral line primordium, a migratory sheet of cells that gives rise to the neuromasts of the posterior lateral line organ. We find that cells within this epithelial tissue constrict actin-rich membranes and enrich apical junction proteins at apical focal points. The coordinated apical membrane constriction in single Delta D-positive hair cell progenitors and in their neighbouring prospective support cells generates cellular rosettes. Live imaging reveals that cellular rosettes subsequently separate from each other and give rise to individual neuromasts. Genetic analysis uncovers an involvement of Lethal giant larvae proteins in the

SUBMITTER: Hava D 

PROVIDER: S-EPMC3188803 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature