Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells.

ABSTRACT:

Background and purpose

Statins, a major component of the prevention of cardiovascular disease, aid progenitor cell functions in vivo and in vitro. Statins bearing a NO-releasing moiety were developed for their enhanced anti-inflammatory/anti-thrombotic properties. Here, we investigated if the NO-donating atorvastatin (NCX 547) improved the functions of circulating angiogenic cells (CACs).

Experimental approach

Circulating angiogenic cells (CACs) were prepared from peripheral blood monocytes of healthy volunteers and type-2 diabetic patients and were cultured in low (LG) or high glucose (HG) conditions, in presence of atorvastatin or NCX 547 (both at 0.1 µM) or vehicle. Functional assays (outgrowth, proliferation, viability, senescence and apoptosis) were performed in presenc

SUBMITTER: Mangialardi G 

PROVIDER: S-EPMC3188894 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature