The treatment of multiple sclerosis with inosine.

ABSTRACT:

Objective

The objective of this study is to evaluate the safety and tolerability of inosine in patients with relapsing-remitting multiple sclerosis (RRMS). The secondary objectives are to assess the effects of inosine administration on serum urate (UA) levels, the progression of neurologic disability, the cumulative number of new, active lesions on magnetic resonance imaging (MRI), and changes in serum levels for markers of inflammation.

Design

Oral administration of inosine was used to raise serum levels of the natural peroxynitrite scavenger UA in 16 patients with RRMS during a 1-year randomized, double-blind trial.

Outcome measures

The endpoints studied were relapse rate, disability assessed by the Kurtzke Expanded Disability Status Scale (EDSS), MRI, and analysis

SUBMITTER: Markowitz CE 

PROVIDER: S-EPMC3189001 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature