Examining the dynamics of chromosomal passenger complex (CPC)-dependent phosphorylation during cell division.

ABSTRACT: The dynamic cellular reorganization needed for successful mitosis requires regulatory cues that vary across microns. The chromosomal passenger complex (CPC) is a conserved regulator involved in key mitotic events such as chromosome-microtubule attachment and spindle midzone formation. Recently, spatial phosphorylation gradients have been reported for CPC substrates, raising the possibility that CPC-dependent signaling establishes order on the micron-length scale in dividing cells. However, this hypothesis has not been tested, largely because of incomplete characterization of the CPC-dependent phosphorylation dynamics. Without these data it is difficult to evaluate perturbations of CPC signaling and select one that alters the spatial organization of substrate phosphorylation at a particular

SUBMITTER: Tan L 

PROVIDER: S-EPMC3189036 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature