Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors.

ABSTRACT: A variety of social behaviors like intermale aggression, fear, and mating rituals are important for sustenance of a species. In mice, these behaviors have been implicated to be mediated by peptide pheromones that are sensed by a class of G protein-coupled receptors, vomeronasal receptor type 2 (V2Rs), expressed in the pheromone detecting vomeronasal organ. Matching V2Rs with their cognate ligands is required to learn what receptors the biologically relevant pheromones are acting on. However, this feat has been greatly limited by the unavailability of appropriate heterologous tools commonly used to study ligand receptor specificity, because this family of receptors fails to traffic to the surface of heterologous cells. Here we show that calreticulin, a housekeeping chaperone commonly expres

SUBMITTER: Dey S 

PROVIDER: S-EPMC3189042 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature