Multi-membership gene regulation in pathway based microarray analysis.

ABSTRACT:

Background

Gene expression analysis has been intensively researched for more than a decade. Recently, there has been elevated interest in the integration of microarray data analysis with other types of biological knowledge in a holistic analytical approach. We propose a methodology that can be facilitated for pathway based microarray data analysis, based on the observation that a substantial proportion of genes present in biochemical pathway databases are members of a number of distinct pathways. Our methodology aims towards establishing the state of individual pathways, by identifying those truly affected by the experimental conditions based on the behaviour of such genes. For that purpose it considers all the pathways in which a gene participates and the general census of gene ex

SUBMITTER: Pavlidis SP 

PROVIDER: S-EPMC3189100 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature