Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure.

ABSTRACT:

Background

Retinoic acid (RA) is important for vertebrate eye morphogenesis and is a regulator of photoreceptor development in the retina. In the zebrafish, RA treatment of postmitotic photoreceptor precursors has been shown to promote the differentiation of rods and red-sensitive cones while inhibiting the differentiation of blue- and UV-sensitive cones. The roles played by RA and its receptors in modifying photoreceptor fate remain to be determined.

Results

Treatment of zebrafish embryos with RA, beginning at the time of retinal progenitor cell proliferation and prior to photoreceptor terminal mitosis, resulted in a significant alteration of rod and cone mosaic patterns, suggesting an increase in the production of rods at the expense of red cones. Quantitative pattern anal

SUBMITTER: Stevens CB 

PROVIDER: S-EPMC3189157 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature