Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women.

ABSTRACT:

Background

Previous studies evaluating the association of vitamin D-related genetic variants with breast cancer risk have produced inconsistent results.

Methods

We evaluated the association between breast cancer risk and 559 single-nucleotide polymorphisms (SNP) in 12 vitamin D-related genes, including 6 genes associated with circulating 25-hydroxyvitamin D [25(OH)D] level identified by recent genome-wide association studies (GWAS), using directly observed and imputed GWAS genotyping data from 2,919 breast cancer cases and 2,323 controls recruited in the Shanghai Breast Cancer Study.

Results

Of the SNPs studied, only rs12570116 in the ACADSB gene, rs4760658 in the VDR gene and rs6091822, rs8124792, and rs6097809 in the CYP24A1 gene, and rs10902845 in C10orf88 had a no

SUBMITTER: Dorjgochoo T 

PROVIDER: S-EPMC3189282 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature