Predictors of breast density change after hormone therapy cessation: results from a randomized trial.

ABSTRACT:

Background

Postmenopausal hormone therapy cessation is associated with a decrease in mammographic density (MD), but it is unknown whether this effect is modified by woman-level characteristics. We investigated whether we could identify characteristics of women who were most likely to experience a decrease in MD due to hormone therapy cessation.

Methods

Postmenopausal hormone therapy users with a prior screening mammogram (n = 1,168) were randomized to continue hormone therapy or to suspend hormone therapy for 1 month or 2 months before their next screening mammogram. We estimated relative risks (RR) and attributable risks with 95% CIs of a ≥7.5% decrease in percentage MD (%MD) versus no change associated with hormone therapy cessation, stratified by age, body mass index (BMI

SUBMITTER: Lowry SJ 

PROVIDER: S-EPMC3189299 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature