Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma.

ABSTRACT:

Aim

The aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD).

Methods

After Institutional Review Board approval, first-degree relatives of patients with EAC/HGD underwent unsedated ultrathin transnasal endoscopy (UUTNE) with biopsy. BE was suspected if any salmon-colored epithelial tongues were seen above the gastroesophageal junction. A diagnosis of BE was made only if biopsy from these areas confirmed columnar-lined epithelium with intestinal metaplasia.

Results

From 23 families, 47 first-degree relatives underwent ultrathin transnasal endoscopy and 1 patient underwent routine upper endoscopy with sedation as part of this study. The

SUBMITTER: Juhasz A 

PROVIDER: S-EPMC3189338 | biostudies-literature | 2011 Nov-Dec

REPOSITORIES: biostudies-literature