New user-friendly approach to obtain an Eisenberg plot and its use as a practical tool in protein sequence analysis.

ABSTRACT: The Eisenberg plot or hydrophobic moment plot methodology is one of the most frequently used methods of bioinformatics. Bioinformatics is more and more recognized as a helpful tool in Life Sciences in general, and recent developments in approaches recognizing lipid binding regions in proteins are promising in this respect. In this study a bioinformatics approach specialized in identifying lipid binding helical regions in proteins was used to obtain an Eisenberg plot. The validity of the Heliquest generated hydrophobic moment plot was checked and exemplified. This study indicates that the Eisenberg plot methodology can be transferred to another hydrophobicity scale and renders a user-friendly approach which can be utilized in routine checks in protein-lipid interaction and in protein and pe

SUBMITTER: Keller RC 

PROVIDER: S-EPMC3189734 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature