Joint inference of population assignment and demographic history.

ABSTRACT: A new approach to assigning individuals to populations using genetic data is described. Most existing methods work by maximizing Hardy-Weinberg and linkage equilibrium within populations, neither of which will apply for many demographic histories. By including a demographic model, within a likelihood framework based on coalescent theory, we can jointly study demographic history and population assignment. Genealogies and population assignments are sampled from a posterior distribution using a general isolation-with-migration model for multiple populations. A measure of partition distance between assignments facilitates not only the summary of a posterior sample of assignments, but also the estimation of the posterior density for the demographic history. It is shown that joint estimates of a

SUBMITTER: Choi SC 

PROVIDER: S-EPMC3189801 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature