Quantification of protein group coherence and pathway assignment using functional association.

ABSTRACT:

Background

Genomics and proteomics experiments produce a large amount of data that are awaiting functional elucidation. An important step in analyzing such data is to identify functional units, which consist of proteins that play coherent roles to carry out the function. Importantly, functional coherence is not identical with functional similarity. For example, proteins in the same pathway may not share the same Gene Ontology (GO) terms, but they work in a coordinated fashion so that the aimed function can be performed. Thus, simply applying existing functional similarity measures might not be the best solution to identify functional units in omics data.

Results

We have designed two scores for quantifying the functional coherence by considering association of GO terms observ

SUBMITTER: Chitale M 

PROVIDER: S-EPMC3189934 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature