Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle.

ABSTRACT:

Background

Ankrd2 (also known as Arpp) together with Ankrd1/CARP and DARP are members of the MARP mechanosensing proteins that form a complex with titin (N2A)/calpain 3 protease/myopalladin. In muscle, Ankrd2 is located in the I-band of the sarcomere and moves to the nucleus of adjacent myofibers on muscle injury. In myoblasts it is predominantly in the nucleus and on differentiation shifts from the nucleus to the cytoplasm. In agreement with its role as a sensor it interacts both with sarcomeric proteins and transcription factors.

Methodology/principal findings

Expression profiling of endogenous Ankrd2 silenced in human myotubes was undertaken to elucidate its role as an intermediary in cell signaling pathways. Silencing Ankrd2 expression altered the expression of genes inv

SUBMITTER: Belgrano A 

PROVIDER: S-EPMC3189947 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature