Identification of gene expression signature modulated by nicotinamide in a mouse bladder cancer model.

ABSTRACT:

Background

Urinary bladder cancer is often a result of exposure to chemical carcinogens such as cigarette smoking. Because of histological similarity, chemically-induced rodent cancer model was largely used for human bladder cancer studies. Previous investigations have suggested that nicotinamide, water-soluble vitamin B3, may play a key role in cancer prevention through its activities in cellular repair. However, to date, evidence towards identifying the genetic alterations of nicotinamide in cancer prevention has not been provided. Here, we search for the molecular signatures of cancer prevention by nicotinamide using a N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced urinary bladder cancer model in mice.

Methodology/principal findings

Via microarray gene expression pr

SUBMITTER: Kim SK 

PROVIDER: S-EPMC3189956 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature