Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness.

ABSTRACT:

Objective

To understand the role in prostate cancer risk and aggressiveness, we investigated the expression in prostate tumor and single nucleotide polymorphisms of SLC5A8. Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis.

Methods

We constructed tissue microarrays from 183 prostate tumor tissues, 43 adjacent non-neoplastic tissues from the same patients, and 13 tissue samples from patients with benign prostatic hyperplasia or prostatic intraepithelial neoplasia. A semiquantitative assessment of SLC5A8 protein expression was determined as the product of immunostaining intensity and the percentage of cells stained. In addition, we compared the frequencies of 4 single

SUBMITTER: Lin HY 

PROVIDER: S-EPMC3190039 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature