RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase.

ABSTRACT: Soluble guanylyl cyclase (sGC) is a key protein in the nitric oxide (NO)/-cGMP signaling pathway. sGC activity is involved in a number of important physiological processes including smooth muscle relaxation, neurotransmission and platelet aggregation and adhesion. Regulation of sGC expression and activity emerges as a crucial factor in control of sGC function in normal and pathological conditions. Recently accumulated evidence strongly indicates that the regulation of sGC expression is a complex process modulated on several levels including transcription, post-transcriptional regulation, translation and protein stability. Presently our understanding of mechanisms governing regulation of sGC expression remains very limited and awaits systematic investigation. Among other ways, the expressio

SUBMITTER: Sharina IG 

PROVIDER: S-EPMC3190046 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature