High-density lipoprotein cholesterol in diabetes: is higher always better?

ABSTRACT:

Background

Recent data suggest that highly elevated high-density lipoprotein cholesterol (HDL-C) may not always protect against cardiovascular disease. To what degree this is true in type 1 diabetes is unknown, although cardiovascular risk is increased despite elevated mean HDL-C.

Objective

To reassess the association between HDL-C and its subfractions with coronary artery disease (CAD) in childhood-onset type 1 diabetes.

Methods

Epidemiology of Diabetes Complications study participants free of CAD at baseline (301 men, 298 women; mean age, 27.1 and diabetes duration, 18.9 years) were studied. CAD was defined as angina, ischemic electrocardiogram changes, confirmed myocardial infarction, angiographic stenosis ≥50%, revascularization, or CAD death. Cholesterol in the H

SUBMITTER: Costacou T 

PROVIDER: S-EPMC3190122 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature