Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis.

ABSTRACT: Obesity is characterized by an expansion of white adipose tissue mass that results from an increase in the size and the number of adipocytes. However, the mechanisms responsible for the formation of adipocytes during development and the molecular mechanisms regulating their increase and maintenance in adulthood are poorly understood. Here, we report the use of leptin-luciferase BAC transgenic mice to track white adipose tissue (WAT) development and guide the isolation and molecular characterization of adipocytes during development using DNA microarrays. These data reveal distinct transcriptional programs that are regulated during murine WAT development in vivo. By using a de novo cis-regulatory motif discovery tool (FIRE), we identify two early gene clusters whose promoters show significan

SUBMITTER: Birsoy K 

PROVIDER: S-EPMC3190384 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature