Spleen transcriptome response to infection with avian pathogenic Escherichia coli in broiler chickens.

ABSTRACT:

Background

Avian pathogenic Escherichia coli (APEC) is detrimental to poultry health and its zoonotic potential is a food safety concern. Regulation of antimicrobials in food-production animals has put greater focus on enhancing host resistance to bacterial infections through genetics. To better define effective mechanism of host resistance, global gene expression in the spleen of chickens, harvested at two times post-infection (PI) with APEC, was measured using microarray technology, in a design that will enable investigation of effects of vaccination, challenge, and pathology level.

Results

There were 1,101 genes significantly differentially expressed between severely infected and non-infected groups on day 1 PI and 1,723 on day 5 PI. Very little difference was seen betwee

SUBMITTER: Sandford EE 

PROVIDER: S-EPMC3190404 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature