The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata.

ABSTRACT: Invasive fungal infections are common clinical complications of neonates, critically ill, and immunocompromised patients worldwide. Candida species are the leading cause of disseminated fungal infections, with Candida albicans being the most prevalent species. Candida glabrata, the second/third most common cause of candidemia, shows reduced susceptibility to a widely used antifungal drug fluconazole. Here, we present findings from a screen of 9134 C. glabrata Tn7 insertion mutants for altered survival profiles in the presence of fluconazole. We have identified two components of RNA polymerase II mediator complex, three players of Rho GTPase-mediated signaling cascade, and two proteins implicated in actin cytoskeleton biogenesis and ergosterol biosynthesis that are required to sustain viabi

SUBMITTER: Borah S 

PROVIDER: S-EPMC3190821 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature