Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection.

ABSTRACT: Influenza vaccines are less effective in older people than younger people. This impaired ability to protect older people from influenza viral lung infection has important implications as older people suffer a higher morbidity and mortality from influenza viral lung infection than younger people. Therefore, the development of novel effective vaccines that induce protection from influenza viral infections in older people are urgently needed. We had previously shown that direct linking the TLR5 activator, flagellin, to viral peptides induces effective immunity to viral antigens in young mice and people, respectively. In this study, we tested the efficacy of this vaccine platform with the hemagglutinin peptide of the influenza A strain virus (vaccine denoted as STF2.HA1-2) in protecting aged m

SUBMITTER: Leng J 

PROVIDER: S-EPMC3191248 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature