The landscape of inherited and de novo copy number variants in a Plasmodium falciparum genetic cross.

ABSTRACT:

Background

Copy number is a major source of genome variation with important evolutionary implications. Consequently, it is essential to determine copy number variant (CNV) behavior, distributions and frequencies across genomes to understand their origins in both evolutionary and generational time frames. We use comparative genomic hybridization (CGH) microarray and the resolution provided by a segregating population of cloned progeny lines of the malaria parasite, Plasmodium falciparum, to identify and analyze the inheritance of 170 genome-wide CNVs.

Results

We describe CNVs in progeny clones derived from both Mendelian (i.e. inherited) and non-Mendelian mechanisms. Forty-five CNVs were present in the parent lines and segregated in the progeny population. Furthermore, extens

SUBMITTER: Samarakoon U 

PROVIDER: S-EPMC3191341 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature