Randomized comparison of systemic anti-inflammatory therapy versus fluocinolone acetonide implant for intermediate, posterior, and panuveitis: the multicenter uveitis steroid treatment trial.

ABSTRACT:

Objective

To compare the relative effectiveness of systemic corticosteroids plus immunosuppression when indicated (systemic therapy) versus fluocinolone acetonide implant (implant therapy) for noninfectious intermediate, posterior, or panuveitis (uveitis).

Design

Randomized controlled parallel superiority trial.

Participants

Patients with active or recently active uveitis.

Methods

Participants were randomized (allocation ratio 1:1) to systemic or implant therapy at 23 centers (3 countries). Implant-assigned participants with bilateral uveitis were assigned to have each eye that warranted study treatment implanted. Treatment-outcome associations were analyzed by assigned treatment for all eyes with uveitis.

Main outcome measures

Masked examiners measured

SUBMITTER: Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group 

PROVIDER: S-EPMC3191365 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature