Stratified assessment of the role of inhaled hypertonic saline in reducing cystic fibrosis pulmonary exacerbations: a retrospective analysis.

ABSTRACT: Objective Limited data exist concerning the role of inhaled hypertonic saline (HS) in decreasing pulmonary exacerbations in cystic fibrosis (CF), especially as more advanced stages of CF lung disease were excluded in prior studies. Herein, the authors retrospectively determined the efficacy of inhaled HS in reducing CF pulmonary exacerbations when stratified according to the severity of CF lung disease. Stratification was based on the framework of the Pulmonary Therapeutics Committee's published gradation of obstructive lung physiology in CF, that is, mild (FEV(1) >70%), moderate (FEV(1) 40-70%) and severe (FEV(1) <40%) lung disease, respectively. Design A retrospective review of the Port CF database over a 3-year period performed at an academic CF care centre. Results 340 pulmonary exac

SUBMITTER: Dmello D 

PROVIDER: S-EPMC3191387 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature