Systematic review of genome-wide expression studies in multiple sclerosis.

ABSTRACT: Background Although recent genome-wide association studies have identified several genetic variants contributing to the complex aetiology of multiple sclerosis (MS), expression and functional studies are required to further understand its molecular basis. Objectives To identify genes and pathways with differential expression in MS. Design The authors conducted a systematic review of seven microarray studies, in which expression in immune cells was compared between MS patients and controls. These studies include a previously unpublished study, which is described here in detail. Results and conclusion Although in general the overlap between studies was poor, 229 genes were found to be differentially expressed in MS in at least two studies, of which 11 were in three studies and HSPA1A in f

SUBMITTER: Kemppinen AK 

PROVIDER: S-EPMC3191406 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature