Identifying Tmem59 related gene regulatory network of mouse neural stem cell from a compendium of expression profiles.

ABSTRACT:

Background

Neural stem cells offer potential treatment for neurodegenerative disorders, such like Alzheimer's disease (AD). While much progress has been made in understanding neural stem cell function, a precise description of the molecular mechanisms regulating neural stem cells is not yet established. This lack of knowledge is a major barrier holding back the discovery of therapeutic uses of neural stem cells. In this paper, the regulatory mechanism of mouse neural stem cell (NSC) differentiation by tmem59 is explored on the genome-level.

Results

We identified regulators of tmem59 during the differentiation of mouse NSCs from a compendium of expression profiles. Based on the microarray experiment, we developed the parallelized SWNI algorithm to reconstruct gene regulatory

SUBMITTER: Zhang L 

PROVIDER: S-EPMC3191490 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature