Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena.

ABSTRACT:

Background

The NAD(+)-dependent histone deacetylases, known as "sirtuins", participate in a variety of processes critical for single- and multi-cellular life. Recent studies have elucidated the importance of sirtuin activity in development, aging, and disease; yet, underlying mechanistic pathways are not well understood. Specific sirtuins influence chromatin structure and gene expression, but differences in their pathways as they relate to distinct chromatin functions are just beginning to emerge. To further define the range of global chromatin changes dependent on sirtuins, unique biological features of the ciliated protozoan Tetrahymena thermophila can be exploited. This system offers clear spatial and temporal separation of multiple whole genome restructuring events critical for

SUBMITTER: Slade KM 

PROVIDER: S-EPMC3191509 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature