Phase II study of tight glycaemic control in COPD patients with exacerbations admitted to the acute medical unit.

ABSTRACT:

Background

Hyperglycaemia is associated with poor outcomes from exacerbations of chronic obstructive pulmonary disease (COPD). Glycaemic control could improve outcomes by reducing infection, inflammation and myopathy. Most patients with COPD are managed on the acute medical unit (AMU) outside intensive care (ICU).

Objective

To determine the feasibility, safety and efficacy of tight glycaemic control in patients on an AMU.

Design

Prospective, non-randomised, phase II, single-arm study of tight glycaemic control in COPD patients with acute exacerbations and hyperglycaemia admitted to the AMU. Participants received intravenous, then subcutaneous, insulin to control blood glucose to 4.4-6.5 mmol/l. Tight glycaemic control was evaluated: feasibility, protocol adherence; ac

SUBMITTER: Archer JR 

PROVIDER: S-EPMC3191583 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature