P53 Family: Role of Protein Isoforms in Human Cancer.

ABSTRACT: TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.

SUBMITTER: Wei J 

PROVIDER: S-EPMC3191818 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature