An MRI-derived definition of MCI-to-AD conversion for long-term, automatic prognosis of MCI patients.

ABSTRACT: Alzheimer's disease (AD) and mild cognitive impairment (MCI) are of great current research interest. While there is no consensus on whether MCIs actually "convert" to AD, this concept is widely applied. Thus, the more important question is not whether MCIs convert, but what is the best such definition. We focus on automatic prognostication, nominally using only a baseline brain image, of whether an MCI will convert within a multi-year period following the initial clinical visit. This is not a traditional supervised learning problem since, in ADNI, there are no definitive labeled conversion examples. It is not unsupervised, either, since there are (labeled) ADs and Controls, as well as cognitive scores for MCIs. Prior works have defined MCI subclasses based on whether or not clinical scores

SUBMITTER: Aksu Y 

PROVIDER: S-EPMC3192038 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature