Semantic processing disturbance in patients with schizophrenia: a meta-analysis of the N400 component.

ABSTRACT:

Background

Theoretically semantic processing can be separated into early automatic semantic activation and late contextualization. Semantic processing deficits have been suggested in patients with schizophrenia, however it is not clear which stage of semantic processing is impaired. We attempted to clarify this issue by conducting a meta-analysis of the N400 component.

Methods

Twenty-one studies met the inclusion criteria for the meta-analysis procedure. The Comprehensive Meta-Analysis software package was used to compute pooled effect sizes and homogeneity.

Results

Studies favoring early automatic activation produced a significant effect size of -0.41 for the N400 effect. Studies favoring late contextualization generated a significant effect size of -0.36 for the N40

SUBMITTER: Wang K 

PROVIDER: S-EPMC3192062 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature