Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment.

ABSTRACT: Targeted therapeutic approaches are increasingly being implemented in the clinic, but early detection of response frequently presents a challenge as many new therapies lead to inhibition of tumor growth rather than tumor shrinkage. Development of novel non-invasive methods to monitor response to treatment is therefore needed. Magnetic resonance spectroscopy (MRS) and magnetic resonance spectroscopic imaging are non-invasive imaging methods that can be employed to monitor metabolism, and previous studies indicate that these methods can be useful for monitoring the metabolic consequences of treatment that are associated with early drug target modulation. However, single-metabolite biomarkers are often not specific to a particular therapy. Here we used an unbiased 1H MRS-based metabolomics ap

SUBMITTER: Lodi A 

PROVIDER: S-EPMC3192145 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature