Beta-2 adrenoceptor genotype and progress in term and late preterm active labor.

ABSTRACT:

Objective

We sought to evaluate whether beta-2 adrenoceptor (β2AR) genotype at a functional polymorphic site encoding for amino acid residue 16 influences rate of cervical dilatation in term and late preterm active labor.

Study design

Subjects who underwent vaginal delivery at ≥34 weeks' gestational age from May 2006 through August 2007 were identified. Each subject had provided venous blood from which DNA was extracted for β2AR genotyping. Digital cervical examinations with paired examination times were collected from intrapartum records. Rate of cervical dilatation in active labor was determined using linear regression. Rates were compared between genotype groups.

Results

Among 401 subjects with satisfactory genotype and intrapartum data, overall rate of active labo

SUBMITTER: Miller RS 

PROVIDER: S-EPMC3192244 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature