BMP signals and the transcriptional repressor BLIMP1 during germline segregation in the mammalian embryo.

ABSTRACT: Molecular factors and tissue compartments involved in the foundation of the mammalian germline have been mainly described in the mouse so far. To find mechanisms applicable to mammals in general, we analyzed temporal and spatial expression patterns of the transcriptional repressor BLIMP1 (also known as PRDM1) and the signaling molecules BMP2 and BMP4 in perigastrulation and early neurulation embryos of the rabbit using whole-mount in situ hybridization and high-resolution light microscopy. Both BMP2 and BMP4 are expressed in annular domains at the boundary of the embryonic disc, which--in contrast to the situation in the mouse--partly belong to intraembryonic tissues. While BMP2 expression begins at (pregastrulation) stage 1 in the hypoblast, BMP4 expression commences--distinctly delayed c

SUBMITTER: Hopf C 

PROVIDER: S-EPMC3192270 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature