Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.

ABSTRACT: Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 μg/mL.

SUBMITTER: Prasad P 

PROVIDER: S-EPMC3192506 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature