Ontology highlight
ABSTRACT:
SUBMITTER: Kanno T
PROVIDER: S-EPMC3192679 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Molecular pain 20110924
In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via β(3) adrenoceptors linked to G(s) protein involving protein kinase A (PKA) activation, to cause allodynia. The present study was conducted to understand how ATP is released from DRG neurons. In an outside-out patch-clamp configuration from acutely dissociated rat DRG neurons, single-channel currents, sensitive to the P2X receptor inhibitor PPADS, were evoked by approaching the ...[more]