The molecular signature underlying the thymic migration and maturation of TCRαβ+ CD4+ CD8 thymocytes.

ABSTRACT:

Background

After positive selection, the newly generated single positive (SP) thymocytes migrate to the thymic medulla, where they undergo negative selection to eliminate autoreactive T cells and functional maturation to acquire immune competence and egress capability.

Methodology/principal findings

To elucidate the genetic program underlying this process, we analyzed changes in gene expression in four subsets of mouse TCRαβ(+)CD4(+)CD8(-) thymocytes (SP1 to SP4) representative of sequential stages in a previously defined differentiation program. A genetic signature of the migration of thymocytes was thus revealed. CCR7 and PlexinD1 are believed to be important for the medullary positioning of SP thymocytes. Intriguingly, their expression remains at low levels in the newly g

SUBMITTER: Teng F 

PROVIDER: S-EPMC3192722 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature